Olaparib Combined with DDR Inhibitors Effectively Prevents EMT and Affects miRNA Regulation in <i>TP53</i>-Mutated Epithelial Ovarian Cancer Cell Lines.

ABSTRACT: Epithelial ovarian cancer (EOC) remains a leading cause of gynecologic cancer mortality. Despite advances in treatment, metastatic progression and resistance to standard therapies significantly worsen patient outcomes. Epithelial-mesenchymal transition (EMT) is a critical process in metastasis, enabling cancer cells to gain invasive and migratory capabilities, often driven by changing miRNA expression involved in the regulation of pathological processes like drug resistance. Targeted therapies like PARP inhibitors (PARPi) have improved outcomes, particularly in BRCA-mutated and DNA repair-deficient tumors; however, resistance and limited efficacy in advanced stages remain challenges. Recent studies highlight the potential synergy of PARPi with DNA damage response (DDR) inhibitors, s

SUBMITTER: Gralewska P 

PROVIDER: S-EPMC11766100 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature