Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer.

ABSTRACT: Bisphenol A (BPA) is a prevalent environmental contaminant found in plastics and known for its endocrine-disrupting properties, posing risks to both human health and the environment. Despite its widespread presence, the impact of BPA on papillary thyroid cancer (PTC) progression, especially under realistic environmental conditions, is not well understood. This study examined the effects of BPA on PTC using a 3D thyroid papillary tumor spheroid model, which better mimicked the complex interactions within human tissues compared to traditional 2D models. Our findings demonstrated that BPA, at environmentally relevant concentrations, could induce significant changes in PTC cells, including a decrease in E-cadherin expression, an increase in vimentin expression, and reduced thyroglobulin (TG) s

SUBMITTER: Huang CY 

PROVIDER: S-EPMC11766120 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature