Comparative Transcriptomic Analysis Reveals New Insights into Spawn Aging in <i>Agaricus bisporus</i>: Mitochondrial Dysfunction.

ABSTRACT: Spawn aging poses a substantial challenge to the Agaricus bisporus industry. This study focuses on the role of mitochondrial dysfunction in the aging process of A. bisporus spawn. We conducted a comprehensive comparative transcriptome analysis to elucidate the molecular mechanisms underlying A. bisporus spawn aging. A total of 1620 genes with significant expression changes between the normal and aged spawn were identified, including 917 up-regulated genes and 703 down-regulated genes. Our results revealed a notable down-regulation of genes involved in carbohydrate metabolism, mitochondrial energy metabolism, reactive oxygen species (ROS) scavenging, repair mechanisms for oxidative stress-induced damage, fatty acid β-oxidation, and amino acid degradation in aged A. b

SUBMITTER: Shu L 

PROVIDER: S-EPMC11766156 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature