Real-Time Biomarkers of Liver Graft Quality in Hypothermic Oxygenated Machine Perfusion.

ABSTRACT: Background: Hypothermic oxygenated machine perfusion has emerged as a strategy to alleviate ischemic-reperfusion injury in liver grafts. Nevertheless, there is limited data on the effectiveness of hypothermic liver perfusion in evaluating organ quality. This study aimed to introduce a readily accessible real-time predictive biomarker measured in machine perfusate for post-transplant liver graft function. Methods: The study evaluated perfusate analytes over a 90-day postoperative period in 26 patients randomly assigned to receive a liver graft following dual hypothermic machine perfusion in a prospective randomized controlled trial. Machine perfusion was consistently conducted end-ischemically for at least 120 min, with real-time perfusate assessment at 30-min intervals. Graft

SUBMITTER: Zhylko A 

PROVIDER: S-EPMC11766178 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature