NLRC3 Attenuates Antiviral Innate Immune Response by Targeting IRF7 in Grass Carp (<i>Ctenopharyngodon idelus</i>).

ABSTRACT: NLRC3 belongs to the NOD-like receptor family and is recognized as a modulator of innate immune mechanisms. In this study, we firstly report that Ctenopharyngodon idelus NLRC3 (CiNLRC3) acts as a negative regulator in the antiviral immune response. Cinlrc3 is ubiquitously expressed across tested tissues, displaying particularly high expression in the intestine, spleen, gill and kidney. Notably, Cinlrc3 expression is markedly upregulated following grass carp reovirus (GCRV) infection both in vivo and in vitro. Functional assays reveal that the overexpression of CiNLRC3 hampers cellular antiviral responses, thereby facilitating viral replication. Conversely, the silencing of CiNLRC3 through siRNA transfection enhances these antiviral activities. Additionall

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11766192 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature