Lovastatin and Resveratrol Synergistically Improve Wound Healing and Inhibit Bacterial Growth.

ABSTRACT: Wound healing is a complex physiological process, with scarring and infection caused by Staphylococcus aureus and Pseudomonas aeruginosa being the most common complications. The reutilization of known medications has received increased attention for their role in cell function as small molecules. Examples of these include lovastatin, a cholesterol-lowering agent, and resveratrol, which have multiple biological properties. Both molecules have been reported to improve wound healing and possess antibacterial properties, with conflicting results. The wound-healing capabilities of human mesenchymal stem cells were evaluated after exposure to lovastatin, resveratrol, and their combination through scratch test, migrations assay, and qPCR. Protein docking was performed to assess the

SUBMITTER: AlJunaydil NA 

PROVIDER: S-EPMC11766293 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature