Stress-Driven Production of γ-Aminobutyric Acid Using Non-Conventional Yeast Strains <i>Kluyveromyces marxianus</i> JMY140K and <i>Metschnikowia reukaufii</i> JMY075.

ABSTRACT: γ-Aminobutyric acid (GABA) is a valuable amino acid widely used in food, healthcare, and agriculture. GABA bioproduction by budding yeasts has been commonly reported, but related studies using non-conventional yeasts remain limited. In this study, two non-conventional natural yeast strains, namely, Kluyveromyces marxianus JMY140K and Metschnikowia reukaufii JMY075, were identified as promising GABA producers, and M. reukaufii JMY075 was discovered to be a GABA producer. Enhanced GABA production was observed in the two yeast strains under stress conditions, including high temperature and high ethanol and acetic acid levels. In particular, K. marxianus JMY140K showed 7.93 times higher GABA titers under thermal stress than that of the control. External stress condi

SUBMITTER: Fan TT 

PROVIDER: S-EPMC11766319 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature