The bacterial composition signatures of perianal abscess and origin of infecting microbes.

ABSTRACT:

Background

Perianal abscess is a common anal condition primarily caused by bacterial infections, yet the precise origins of these infecting bacteria remain unclear. Understanding the distinct microbial signatures associated with periaabscesses is crucial for provide fresh ideas for disease prevention.

Materials and methods

Samples of anal skin, feces, and abscesses were collected from a cohort of 75 patients diagnosed with perianal abscesses. The microbial composition at each site was analyzed using 16S rRNA gene sequencing to characterize the bacterial communities present.

Results

Analysis using MaAslin2 revealed distinct bacterial compositional signatures among the anal skin, feces, and abscess samples. Alpha diversity analysis indicated significant differences in b

SUBMITTER: Han S 

PROVIDER: S-EPMC11766672 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature