Lipidomics of Huntington's Disease: A Comprehensive Review of Current Status and Future Directions.

ABSTRACT:

Background

Huntington's disease (HD) is a multifaceted neurological disorder characterized by the progressive deterioration of motor, cognitive, and psychiatric functions. Despite a limited understanding of its pathogenesis, research has implicated abnormal trinucleotide cytosine-adenine-guanine CAG repeat expansion in the huntingtin gene (HTT) as a critical factor. The development of innovative strategies is imperative for the early detection of predictive biomarkers, enabling timely intervention and mitigating irreversible cellular damage. Lipidomics, a comprehensive analytical approach, has emerged as an indispensable tool for systematically characterizing lipid profiles and elucidating their role in disease pathology.

Method

A MedLine search was performed to identify stu

SUBMITTER: Yilmaz A 

PROVIDER: S-EPMC11766911 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature