Investigating Metabolic Phenotypes for Sarcoidosis Diagnosis and Exploring Immunometabolic Profiles to Unravel Disease Mechanisms.

ABSTRACT: Background: Sarcoidosis is a granulomatous disease affecting multiple organ systems and poses a diagnostic challenge due to its diverse clinical manifestations and absence of specific diagnostic tests. Currently, blood biomarkers such as ACE, sIL-2R, CD163, CCL18, serum amyloid A, and CRP are employed to aid in the diagnosis and monitoring of sarcoidosis. Metabolomics holds promise for identifying highly sensitive and specific biomarkers. This study aimed to leverage metabolomics for the early diagnosis of sarcoidosis and to identify metabolic phenotypes associated with disease progression. Methods: Serum samples from patients with sarcoidosis (n = 40, including stage 1 to stage 4), were analyzed for metabolite levels by semi-untargeted liquid chromatography-mass spect

SUBMITTER: Banoei MM 

PROVIDER: S-EPMC11766916 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature