'Ship-in-a-Bottle' Integration of pH-Sensitive 3D Proteinaceous Meshes into Microfluidic Channels.

ABSTRACT: Microfluidic sensors incorporated onto chips allow sensor miniaturization and high-throughput analyses for point-of-care or non-clinical analytical tools. Three-dimensional (3D) printing based on femtosecond laser direct writing (fs-LDW) is useful for creating 3D microstructures with high spatial resolution because the structures are printed in 3D space along a designated laser light path. High-performance biochips can be fabricated using the 'ship-in-a-bottle' integration technique, in which functional microcomponents or biomimetic structures are embedded inside closed microchannels using fs-LDW. Solutions containing protein biomacromolecules as a precursor can be used to fabricate microstructures that retain their native protein functions. Here, we demonstrate the ship-in-a-bottle integr

SUBMITTER: Serien D 

PROVIDER: S-EPMC11767245 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature