LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling.

ABSTRACT: Blood microsampling (BμS) has recently emerged as an interesting approach in the analysis of endogenous metabolites but also in metabolomics applications. Their non-invasive way of use and the simplified logistics that they offer renders these technologies highly attractive in large-scale studies, especially the novel quantitative microsampling approaches such as VAMs or qDBS. Objectives: Herein, we investigate the potential of BµS devices compared to the conventional plasma samples used in global untargeted mass spectrometry-based metabolomics of blood. Methods: Two novel quantitative devices, namely, Mitra, Capitainer, and the widely used Whatman cards, were selected for comparison with plasma. Venous blood was collected from 10 healthy, overnight-fasted individuals and loa

SUBMITTER: Thaitumu MN 

PROVIDER: S-EPMC11767270 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature