NupR Is Involved in the Control of PlcR: A Pleiotropic Regulator of Extracellular Virulence Factors.

ABSTRACT: NupR is a nucleoside permease regulator belonging to the GntR family, mainly regulating nucleoside transport in Bacillus thuringiensis. A conserved binding site for NupR was found in the promoter region of plcR. This study aimed to investigate the regulation of the virulence regulator PlcR by NupR and its impact on Bt virulence. We demonstrated that NupR can directly repress the expression of plcR. The expression of plcR can be induced by glucose and nucleosides. Glucose impacts the expression of plcR mainly through Spo0A, while the induction effect of nucleosides may be due to the production of ribose through nucleoside catabolism. In addition, NupR regulates the expression of the PlcR regulon, including hemolysin, phospholipase C, papR, and oligo

SUBMITTER: Qin J 

PROVIDER: S-EPMC11767619 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature