New Oxygenated Methoxy-<i>p</i>-Cymene Derivatives from Leopard's Bane (<i>Doronicum columnae</i> Ten., Asteraceae) Essential Oil: Synthesis Facilitating the Identification of Isomeric Minor Constituents in Complex Matrices.

ABSTRACT: Species of the genus Doronicum are known for their pharmacological properties and essential oils, the chemical composition of which remains inadequately studied. In this work, GC-MS analysis, synthesis, and spectral techniques (UV, IR, MS, and NMR) were employed to identify 83 constituents in the essential oil from D. columnae roots, which accounted for 98.1% of the total GC-peak area. The major components were thymyl isobutyrate (32.8%) and thymyl 2-methylbutyrate (22.8%), while the minor constituents were methoxy-p-cymene derivatives. Six new natural products were identified through synthesis, GC co-injection experiments and spectral characterization, including esters (isobutyrate, 2-methylbutyrate, and/or isovalerate) of 2-methoxycuminol, 6-methoxythymol, and 6-hydr

SUBMITTER: Dimitrijevic MZ 

PROVIDER: S-EPMC11767694 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature