Calcium Phosphate Nanoparticles Functionalized with a Cardio-Specific Peptide.

ABSTRACT: Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, highliting the urgent need for new therapeutic strategies. Peptide-based therapies have demonstrated significant potential for treating CVDs; however, their clinical application is hindered by their limited stability in physiological fluids. To overcome this challenge, an effective drug delivery system is essential to protect and efficiently transport peptides to their intended targets. This study introduces two distinct strategies for loading a cardio-specific mimetic peptide (MP), previously designed to modulate L-type calcium channel function in cardiomyocytes, onto calcium phosphate nanoparticles (CaP NPs). MP-loaded CaP NPs were prepared by two different wet precipitation syntheses, one of which involved t

SUBMITTER: Mancini F 

PROVIDER: S-EPMC11767714 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature