Aquatic Invertebrate Antimicrobial Peptides in the Fight Against Aquaculture Pathogens.

ABSTRACT: The intensification of aquaculture has escalated disease outbreaks and overuse of antibiotics, driving the global antimicrobial resistance (AMR) crisis. Antimicrobial peptides (AMPs) provide a promising alternative due to their rapid, broad-spectrum activity, low AMR risk, and additional bioactivities, including immunomodulatory, anticancer, and antifouling properties. AMPs derived from aquatic invertebrates, particularly marine-derived, are well-suited for aquaculture, offering enhanced stability in high-salinity environments. This study compiles and analyzes data from AMP databases and over 200 scientific sources, identifying approximately 350 AMPs derived from aquatic invertebrates, mostly cationic and α-helical, across 65 protein families. While in vitro assays highlight their potentia

SUBMITTER: Rodrigues T 

PROVIDER: S-EPMC11767717 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature