Investigating SARS-CoV-2 Neutralising Antibody Response in Sheep.

ABSTRACT: SARS-CoV-2 can cause clinical and inapparent disease and mortality in several animals cohabitating with humans, and sheep are susceptible to SARS-CoV-2 due to virus-receptor interactions similar to those in humans. Hence, sheep have the potential to be infected, spread, and develop neutralising antibodies (NAbs) against SARS-CoV-2. The aim of this study was to investigate the prevalence of SARS-CoV-2 NAbs in farm animals after natural exposure to the virus. Serum samples were collected from sheep in the Serra da Estrela region in Portugal, both prior to and during the COVID-19 pandemic. The sera were tested by established SARS-CoV-2 pseudovirus systems for multiple SARS-CoV-2 variants (early-Wuhan, mid-Delta, Omicron-BA.1, and late-Omicron XBB, BQ.1.1). Partial neutralisation activity in P

SUBMITTER: Samojlovic M 

PROVIDER: S-EPMC11767788 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature