Maternal Glycemia and Its Pattern Associated with Offspring Neurobehavioral Development: A Chinese Birth Cohort Study.

ABSTRACT:

Background/objectives

This study investigates the impact of maternal glycemic levels during early and late pregnancy on offspring neurodevelopment in China.

Methods

Fasting plasma glucose (FPG) and triglyceride (TG) levels were measured in maternal blood during pregnancy, and the TyG index was calculated to assess insulin resistance. Hyperglycemia was defined as FPG > 5.1 mmol/L. Neurodevelopmental outcomes in offspring aged 6-36 months were evaluated using the China Developmental Scale for Children, focusing on developmental delay (DD) and developmental quotient (DQ). Mothers were categorized into four glycemic groups: healthy glycemia group (HGG), early pregnancy hyperglycemia group (EHG), late pregnancy hyperglycemia group (LHG), and full-term hyperglycemia group (FHG). L

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC11767945 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature