Isolation and Bioactivity of Natural Products from <i>Streptomyces</i> sp. MA37.

ABSTRACT: The isolation and characterization of bioactive metabolites from Streptomyces species continue to represent a vital area of research, given their potential in natural product drug discovery. In this study, we characterize a new siderophore called legonoxamine I, together with a known compound, streptimidone, from the talented soil bacterium Streptomyces sp. MA37, using chromatographic techniques and spectroscopic analysis. Legonoxamine I is a new holo-siderophore, which is likely to be a derailed product from the biosynthetic pathway of legonoxamine A. We also demonstrate that legonoxamine A possesses potent anticancer activity (IC₅₀ = 2.2 µM), exhibiting a remarkable ~30-fold increase in potency against MCF-7 ATCC HTB-22 breast cancer cells compared to desferrioxa

SUBMITTER: Maglangit F 

PROVIDER: S-EPMC11767966 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature