Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESI⁺-MS.

ABSTRACT:

Background

Pregnancy induces significant physiological and metabolic changes in the mother to support fetal growth and prepare for childbirth. These adaptations impact various systems, including immune tolerance, metabolism, and endocrine function. While metabolomics has been utilized to study pregnancy-related metabolic changes, comprehensive comparisons between pregnant and non-pregnant states, particularly using ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLC-MS), remain limited.

Methods

This study aimed to explore the dynamic, longitudinal metabolic shifts during pregnancy by profiling plasma samples from 65 pregnant women across three time points (6-14 weeks, 14-22 weeks, and >24 weeks) and 42 postpartum women. Lipidomics was prioritiz

SUBMITTER: Traila A 

PROVIDER: S-EPMC11768031 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature