Efficacy of <i>N</i>-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age and requires better treatment. N-acetylcysteine (NAC) is known to be beneficial under such conditions owing to its antioxidant potential and insulin-sensitizing properties. The effect of NAC on the reproductive outcomes of PCOS patients was examined in this meta-analysis.

Methods

In accordance with PRISMA standards, this meta-analysis included studies that compared N-acetylcysteine, metformin, clomiphene citrate, and a placebo in patients with POCS. The main indicators were follicular growth, endometrial thickness, and hormone level. The risk of bias was evaluated using the Cochrane ROB2 tool.

Results

Twenty-two studies (n = 2515) were

SUBMITTER: Vina I 

PROVIDER: S-EPMC11768055 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature