On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (Actaea racemosa L.).

ABSTRACT: Botanical dietary supplements are widely used, but issues of authenticity, consistency, safety, and efficacy that complicate their poorly understood mechanism of action have prompted questions and concerns in the popular and scientific literature. Black cohosh (Actaea racemosa L., syn. Cimicifuga racemosa, Nutt., Ranunculaceae) is a multicomponent botanical therapeutic used as a popular remedy for menopause and dysmenorrhea and explored as a treatment in breast and prostate cancer. However, its use and safety are controversial. A. racemosa tissues contain the bioactive serotonin analog N-methylserotonin, which is thought to contribute to the serotonergic activities of black cohosh-containing preparations. A. racemosa has several TDC-like genes hypo

SUBMITTER: Spiering MJ 

PROVIDER: S-EPMC11768127 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature