ABSTRACT: Plants have long been used to treat serious illnesses in both humans and animals. A significant underappreciated medicinal tree, Peltophorum africanum Sond is utilized by many different ethnic groups to cure a wide range of illnesses. A variety of electronic databases, including ScienceDirect, Scopus, Scielo, Scifinder, PubMed, Web of Science, Medline, and Google Scholar, were used to search the literature on P. africanum, using key words such as uses, survey, pharmacology, antigonococcal, toxicity, phytochemistry and others. Further data was obtained from several scholarly theses, dissertations, and books on general plant sciences, ethnomedicine, and other pertinent ethnobotanical topics. The plant species possess very important pharmacological activities in vitro, which inc