Multivalent Neuroprotective Activity of <i>Elettaria cardamomum</i> (Cardamom) and <i>Foeniculum vulgare</i> (Fennel) in H₂O₂-Induced Oxidative Stress in SH-SY5Y Cells and Acellular Assays.

ABSTRACT:

Background

Elettaria cardamomum (Cardamom) and Foeniculum vulgare (Fennel) are well-known spices and are also used as natural mouth fresheners. This study was performed to evaluate their neuroprotective ability based on certain acellular and cellular assays.

Methods

Hexane and ethyl acetate extracts were prepared using cardamom and fennel seeds. GC/MS was performed for the identification of important bioactive compounds. Cell-based assays were performed using SH-SY5Y cells. Hydrogen peroxide was used for the induction of oxidative stress, and evaluation was done based on neuroprotection, reduced reactive oxygen species, and restoration of mitochondrial membrane potential (MMP). Additionally, anti-Aβ fibrillization/oligomerization activities were also analyzed a

SUBMITTER: Sharma H 

PROVIDER: S-EPMC11768314 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature