Production of Hydrophobic Microparticles at Safe-To-Inject Sizes for Intravascular Administration.

ABSTRACT: Background/Objectives: Hydrophobic microparticles are one of the most versatile structures in drug delivery and tissue engineering. These constructs offer a protective environment for hydrophobic or water-sensitive compounds (e.g., drugs, peroxides), providing an optimal solution for numerous biomedical purposes, such as drug delivery or oxygen therapeutics. The intravascular administration of hydrophobic microparticles requires a safe-to-flow particle profile, which typically corresponds to a maximum size of 5 µm-the generally accepted diameter for the thinnest blood vessels in humans. However, the production of hydrophobic microparticles below this size range remains largely unexplored. In this work, we investigate the fabrication of hydrophobic microparticles at safe-to-inject an

SUBMITTER: Gomes FL 

PROVIDER: S-EPMC11768317 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature