An Investigation of the Anticancer Mechanism of <i>Caesalpinia sappan</i> L. Extract Against Colorectal Cancer by Integrating a Network Pharmacological Analysis and Experimental Validation.

ABSTRACT: Caesalpinia sappan L. has exhibited various pharmacological effects, yet its anticancer activities against colorectal cancer (CRC) and underlying molecular mechanisms remain unclear. This study investigated the anticancer properties of an ethanol extract of C. sappan L. (CSE) against CRC cells, focusing on the identification of bioactive compounds and their mechanisms of action. A network pharmacology analysis was conducted to identify potential CRC targets and bioactive compounds of CSE, using LC-MS for compound identification. The anticancer effects of CSE were then validated through in vitro and in vivo models of CRC. The network pharmacological approach identified 87 overlapping genes between CSE targets and CRC-related genes, with protein-protein interaction analysis hig

SUBMITTER: Jeong M 

PROVIDER: S-EPMC11768342 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature