Exploring Gender Differences in the Effects of Diet and Physical Activity on Metabolic Parameters.

ABSTRACT:

Background

Gender differences in metabolic response to lifestyle interventions remain poorly explored. This study aimed to evaluate the impact of a six-month Mediterranean diet (MD) intervention combined with regular physical activity on metabolic parameters in overweight adults.

Methods

A prospective cohort study was conducted in an obesity clinic in Rome, Italy, involving overweight adults (BMI ≥ 25 kg/m²) motivated to improve their lifestyle. Participants (n = 205; 107 men and 98 women) self-selected into physical activity groups (aerobic, anaerobic, combined or no activity). Gender-specific metabolic changes were assessed, including lipid profiles, liver markers and fasting glucose.

Results

Significant gender differences in metabolic results were

SUBMITTER: Gorini S 

PROVIDER: S-EPMC11768364 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature