Ashwagandha: Optimizing the Extraction and Electrospun Nanofiber Production.

ABSTRACT: Background/Objectives: This study explores the development of electrospun nanofibers incorporating bioactive compounds from Withania somnifera (Ashwagandha) root extract, focusing on optimizing extraction conditions and nanofiber composition to maximize biological activity and application potential. Methods: Using the Design of Experiment (DoE) approach, optimal extraction parameters were identified as 80% methanol, 70 °C, and 60 min, yielding high levels of phenolic compounds and antioxidant activity. Methanol concentration emerged as the critical factor influencing phytochemical properties. Electrospinning technology was employed to produce nanofibers using polyvinylpyrrolidone (PVP) and hydroxypropyl-β-cyclodextrin (HPβCD) as carriers, ensuring encapsulation, stabil

SUBMITTER: Jaskolski M 

PROVIDER: S-EPMC11768389 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature