A Pilot Study Exploring the Relationship Between Milk Composition and Microbial Capacity in Breastfed Infants.

ABSTRACT:

Background

Maternal obesity may contribute to childhood obesity in a myriad of ways, including through alterations of the infant gut microbiome. For example, maternal obesity may contribute both directly by introducing a dysbiotic microbiome to the infant and indirectly through the altered composition of human milk that fuels the infant gut microbiome. In particular, indigestible human milk oligosaccharides (HMOs) are known to shape the composition of the infant gut microbiome. The goal of this study was to characterize the HMO profiles of normal-weight and overweight mothers and to quantitatively link HMO concentrations to the taxonomic composition and functional potential of the infant gut microbiome.

Methods

Normal-weight (BMI = 18.5-24.9; n = 9) and overweight/obe

SUBMITTER: Fricker AD 

PROVIDER: S-EPMC11768495 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature