Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma.

ABSTRACT: Objectives: This in vivo study introduces a newly developed spirooxindole derivative that is deemed safe and effective as a potential targeted therapy for various cancers. Methods: Extensive in vivo investigations, including histopathology, immunohistochemistry, and molecular biology, validated its potential for further preclinical and clinical exploration, necessitating comprehensive examinations of its bioavailability, pharmacodynamics, and pharmacokinetics. Additionally, this study involves the development of a commercially viable proniosomal drug delivery system for the compound, facilitating controlled drug release. Results: The data revealed efficacy of spirooxindole derivative in halting the progression of liver cancer, metastasis, and portal vein thrombosis, wi

SUBMITTER: Barakat A 

PROVIDER: S-EPMC11768502 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature