Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy.

ABSTRACT:

Background/objectives

Septic cardiomyopathy (SCM) is a severe cardiac complication of sepsis, characterized by cardiac dysfunction with limited effective treatments. This study aimed to identify repurposable drugs for SCM by integrated multi-omics and network analyses.

Methods

We generated a mouse model of SCM induced by lipopolysaccharide (LPS) and then obtained comprehensive metabolic and genetic data from SCM mouse hearts using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and RNA sequencing (RNA-seq). Using network proximity analysis, we screened for FDA-approved drugs that interact with SCM-associated pathways. Additionally, we tested the cardioprotective effects of two drug candidates in the SCM mouse model and explored their mechanism-o

SUBMITTER: Liu PP 

PROVIDER: S-EPMC11768530 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature