Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery.

ABSTRACT: Cyclodextrins can serve as carriers for various payloads, utilizing their capacity to form unique host-guest inclusion complexes within their cavity and their versatile surface functionalization. Recently, cationic cyclodextrins have gained considerable attention, as they can improve drug permeability across negatively charged cell membranes and efficiently condense negatively charged nucleic acid due to electrostatic interactions. This review focuses on state-of-the-art and recent advances in the construction of cationic cyclodextrin-based delivery systems. First, we identified different cationic moieties that are commonly employed in the design of cyclodextrins with enhanced complexation ability. Subsequently, a wide range of cationic cyclodextrin-based drug delivery systems were analyze

SUBMITTER: Nazli A 

PROVIDER: S-EPMC11768558 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature