Development of a Hydrocortisone Orodispersible Thin Film Containing Its Succinate Prodrug.

ABSTRACT: Orodispersible thin film (ODF) is an innovative dosage form that allows for adjustable dosing and improved patient compliance. It is administered by mouth, where it dissolves, making it suitable for children.

Objectives

The aim of the study was to develop and characterize an optimal ODF formulation containing equivalent hydrocortisone at 0.5 mg/cm² using the solvent-casting method. A stability-indicating assay for the simultaneous quantification of hydrocortisone and hydrocortisone 21-hemissucinate (HMS) was developed. ODFs were characterized by organoleptic properties and by testing for uniformity of mass, content, stability, thickness, and dissolution.

Results

When optimized, ODF is thin, flexible, and transparent, making it suitable for production in hospital ph

SUBMITTER: Boisseillier C 

PROVIDER: S-EPMC11768698 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature