Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease.

ABSTRACT: Enterovirus-D68 (EV68) continues to present as a global health issue causing respiratory illness and outbreaks associated with long-lasting neurological disease, with no antivirals or specific treatment options. The development of antiviral therapeutics, such as small-molecule inhibitors that target conserved proteins like the enteroviral 3C protease, remains to be achieved. While various 3C inhibitors have been investigated, their design does not consider the potential emergence of drug resistance mutations. For other antivirals where resistance has been a challenge, we have demonstrated that the likelihood of resistance can be minimized by designing inhibitors that leverage the evolutionary constraints of the target. Here, we characterize a series of 3C inhibitors against EV68-3C proteas

SUBMITTER: Azzolino VN 

PROVIDER: S-EPMC11768739 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature