Nanoparticle-in-Hydrogel Delivery System for the Sequential Release of Two Drugs.

ABSTRACT:

Background/objectives

Glioblastoma is the most common and lethal primary brain tumor. Patients often suffer from tumor- and treatment induced vasogenic edema, with devastating neurological consequences. Intracranial edema is effectively treated with dexamethasone. However, systemic dexamethasone requires large doses to surpass the blood brain barrier in therapeutic quantities, which is associated with significant side effects. The aim of this study was to investigate a biodegradable, dextran-hydroxyethyl methacrylate (dex-HEMA) based hydrogel, containing polymeric micelles loaded with dexamethasone and liposomes encapsulating dexamethasone phosphate for localized and prolonged delivery.

Methods

Poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide (m

SUBMITTER: van Straten D 

PROVIDER: S-EPMC11768762 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature