Persistence of the Immune Response to an Intramuscular Bivalent (GI.1/GII.4) Norovirus Vaccine in Adults.

ABSTRACT:

Background

Major global economic and health burdens due to norovirus gastroenteritis could be addressed by an effective vaccine.

Methods

In this study, 428 adult recipients of various compositions of the norovirus vaccine candidate, HIL-214, were followed for 5 years, to assess immune responses to its virus-like particle antigens, GI.1 and GII.4c. Serum antibodies and peripheral-blood antibody-secreting cells (ASCs) were measured. This report focuses on the single-dose 15/50 (µg GI.1/GII.4c) composition, which had been selected for further clinical development.

Results

For single-dose 15/50 recipients (N = 105), GI.1-specific and GII.4c-specific histoblood-group antigen-blocking (HBGA) antibodies appeared to have persisted to 5 years, waning from a peak at 4 to 8 week

SUBMITTER: Leroux-Roels G 

PROVIDER: S-EPMC11768790 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature