Exploiting the Achilles' Heel of Viral RNA Processing to Develop Novel Antivirals.

ABSTRACT: Treatment options for viral infections are limited and viruses have proven adept at evolving resistance to many existing therapies, highlighting a significant vulnerability in our defenses. In response to this challenge, we explored the modulation of cellular RNA metabolic processes as an alternative paradigm to antiviral development. Previously, the small molecule 5342191 was identified as a potent inhibitor of HIV-1 replication by altering viral RNA accumulation at doses that minimally affect host gene expression. In this report, we document 5342191 as a potent inhibitor of adenovirus, coronavirus, and influenza replication. In each case, 5342191-mediated reduction in virus replication was associated with altered viral RNA accumulation and loss of viral structural protein expression. Int

SUBMITTER: Zahedi Amiri A 

PROVIDER: S-EPMC11768839 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature