Dual-Mechanism Gastroretentive Tablets with Encapsulated Gentian Root Extract.

ABSTRACT: Background/Objectives: This study aimed to develop gastroretentive tablets based on mucoadhesive-floating systems with encapsulated gentian (Gentiana lutea, Gentianaceae) root extract to overcome the low bioavailability and short elimination half-life of gentiopicroside, a dominant bioactive compound with systemic effect. The formulation also aimed to promote the local action of the extract in the stomach. Methods: Tablets were obtained by direct compression of sodium bicarbonate (7.5%) and solid lipid microparticles (92.5%), which were obtained with lyophilizing double emulsions. A quality by design (QbD) was employed to evaluate the impact of formulation factors and processing parameters on emulsion viscosity, powder characteristics (moisture content, encapsulation e

SUBMITTER: Mudric J 

PROVIDER: S-EPMC11768846 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature