Ultrasonic Deposition of Cellulose Nanocrystals on Substrates for Enhanced Eradication Activity on Multidrug-Resistant Pathogens.

ABSTRACT: Amidst the pervasive threat of bacterial afflictions, the imperative for advanced antibiofilm surfaces with robust antimicrobial efficacy looms large. This study unveils a sophisticated ultrasonic synthesis method for cellulose nanocrystals (CNCs, 10-20 nm in diameter and 300-900 nm in length) and their subsequent application as coatings on flexible substrates, namely cotton (CC-1) and membrane (CM-1). The cellulose nanocrystals showed excellent water repellency with a water contact angle as high as 148° on the membrane. Noteworthy attributes of CNC-coated substrates include augmented reactive oxygen species (ROS) generation, heightened surface hydrophobicity, and comprehensive suppression of both drug-sensitive (MDR E. coli and MRSA) and susceptible (E. coli and S.

SUBMITTER: Jabreen L 

PROVIDER: S-EPMC11769134 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature