In Vivo Imaging of Cardiac Attachment of TcI and TcII Variants of <i>Trypanosoma cruzi</i> in a Zebrafish Model.

ABSTRACT: Trypanosoma cruzi, the etiological agent of Chagas disease, is a parasite known for its diverse genotypic variants, or Discrete Typing Units (DTUs), which have been associated with varying degrees of tissue involvement. However, aspects such as parasite attachment remain unclear. It has been suggested that the TcI genotype is associated with cardiac infection, the most common involved site in chronic human infection, while TcII is associated with digestive tract involvement. Traditional models for T. cruzi infection provide limited in vivo observation, making it challenging to observe the dynamics of parasite-host interactions. This study evaluates the cardiac attachment of trypomastigotes from TcI and TcII DTUs in zebrafish larvae. Labeled trypomastigotes were injected in th

SUBMITTER: Rodriguez-Castellanos VE 

PROVIDER: S-EPMC11769151 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature