Beeswax Alcohol (BWA, Raydel^®) Improved Blood Oxidative Variables and Ameliorated Severe Damage of Zebrafish Kidneys, Testes, and Ovaries Impaired by 24-Week Consumption of a High-Cholesterol and High-Galactose Diet: A Comparative Analysis with Coenzyme Q₁₀.

ABSTRACT:

Objectives

The present study describes the comparative effect of 24-week supplementation of beeswax alcohol (BWA, Raydel^®, 0.5% and 1.0%, wt/wt) and coenzyme Q₁₀ (CoQ₁₀, 0.5% and 1.0%, wt/wt) on plasma oxidative variables and the prevention of organ injury in adult zebrafish subjected to a high-cholesterol (HC, 4%, wt/wt) and -D-galactose (Gal, 30%, wt/wt) diet.

Methods

Adult zebrafish were fed various HC+Gal diets enriched with either BWA or CoQ₁₀. After 24 weeks of dietary intervention, blood and organs were harvested for subsequent biochemical and histological evaluations.

Results

The HC+Gal-elevated plasma oxidative variables were reverted by the consumption of BWA, marked by the lowest plasma malondialdehyde (MDA) level

SUBMITTER: Cho KH 

PROVIDER: S-EPMC11769329 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature