Responses of an <i>In Vitro</i> Coculture Alveolar Model for the Prediction of Respiratory Sensitizers (ALIsens^®) Following Exposure to Skin Sensitizers and Non-Sensitizers.

ABSTRACT: In recent years, a global increase in allergy incidence following chemical exposure has been observed. While the process of skin sensitization is well characterized through the adverse outcome pathway (AOP) framework, the immunological mechanisms underlying respiratory sensitization remain less well understood. Respiratory sensitizers are classified as substances of very high concern (SVHC) under the European Union (EU) regulation for the registration, evaluation, authorization and restriction of chemicals (REACH), emphasizing the importance of evaluating respiratory tract sensitization as a critical hazard. However, the existing new approach methodologies (NAMs) for the identification of skin sensitizers lack the capacity to differentiate between skin and respiratory sensitizers. Thus, it

SUBMITTER: Burla S 

PROVIDER: S-EPMC11769448 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature