Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma.

ABSTRACT: Background/Objectives: The two obstacles for treating glioma are the skull and the blood brain-barrier (BBB), the first of which forms a physical shield that increases the difficulties of traditional surgery or radiotherapy, while the latter prevents antitumor drugs reaching tumor sites. To conquer these issues, we take advantage of the high penetrating ability of sonodynamic therapy (SDT), combined with a novel nanocomplex that can easily pass the BBB. Methods: Through ultrasonic polymerization, the amphiphilic peptides (C₁₈GR₇RGDS) were self-assembled as a spherical shell encapsulating a sonosensitizer Rose Bengal (RB) and a plant-derived compound, sulforaphane (SFN), to form the nanocomplex SFN@RB@SPM. Results/Conclusions: SFN@RB@SPM can be int

SUBMITTER: Li Y 

PROVIDER: S-EPMC11769538 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature