Benefit of implantable cardioverter defibrillator use in Japanese patients based on modified MADIT-ICD benefit score.

ABSTRACT:

Aims

The MADIT-ICD benefit score is used to stratify the risk of life-threatening arrhythmia and non-arrhythmic mortality. We sought to develop an implantable cardioverter defibrillator (ICD) benefit-prediction score for Japanese patients with ICDs.

Methods

Patients who underwent ICD implantation as primary prophylaxis were retrospectively enrolled. Based on their MADIT-ICD benefit scores, we developed a modified MADIT-ICD benefit score adapted to the Japanese population. The primary endpoints were appropriate ICD therapy and all-cause death without appropriate ICD therapy (non-arrhythmic death). We used the Fine and Gray multivariate model and Cox proportional hazard regression to identify factors for adjusting the MADIT-ICD benefit-risk score specifically for the Japanese

SUBMITTER: Chiba T 

PROVIDER: S-EPMC11769601 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature