Proteomics of left ventricular structure in the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Aims

Proteomic profiling offers an expansive approach to biomarker discovery and mechanistic hypothesis generation for LV remodelling, a critical component of heart failure (HF). We sought to identify plasma proteins cross-sectionally associated with left ventricular (LV) size and geometry in a diverse population-based cohort without known cardiovascular disease (CVD).

Methods and results

Among participants of the Multi-Ethnic Study of Atherosclerosis (MESA), we quantified plasma abundances of 1305 proteins using an aptamer-based platform at exam 1 (2000-2002) and exam 5 (2010-2011) and assessed LV structure by cardiac magnetic resonance (CMR) at the same time points. We used multivariable linear regression with robust variance to assess cross-sectional associations between

SUBMITTER: Peterson TE 

PROVIDER: S-EPMC11769605 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature