Catestatin as a predictor for cardiac death in heart failure with mildly reduced and preserved ejection fraction.

ABSTRACT:

Aims

Endogenous catecholamine release-inhibitory peptide catestatin has been associated with heart failure (HF). This subgroup analysis of our cohort of HF compared the different effects of catestatin as a predictor for cardiac outcomes in patients with HF with reduced (HFrEF), mildly reduced (HFmrEF) or preserved (HFpEF) ejection fraction.

Methods

Plasma catestatin was measured in the HF patient cohort of 228 cases with a whole spectrum of ejection fraction. The cardiac deaths were analysed according to prespecified subgroups.

Results

Over a median follow-up of 52.5 months, the association between plasma catestatin and cardiac death was different in patients with HFrEF, HFmrEF or HFpEF [hazard ratio (HR) 1.53, 95% confidence interval (CI) 0.99-2.37 and HR 2.73, 95% C

SUBMITTER: Chu SY 

PROVIDER: S-EPMC11769630 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature