Frailty in heart failure according to the presence or absence of wild-type transthyretin cardiac amyloidosis.

ABSTRACT:

Aims

Wild-type transthyretin cardiac amyloidosis (ATTRwt CA) is a common, underdiagnosed cause of heart failure (HF) in the elderly. Concurrent extracardiac amyloid infiltration might be responsible for a specific frailty phenotype. This study aims to compare the prevalence and characteristics of frailty parameters in HF patients, with or without ATTRwt CA.

Methods

In a comparative cross-sectional study, we prospectively included consecutive HF patients with or without ATTRwt CA (the HF + ATTRwt+ and HF + ATTRwt- groups, respectively) between April 2018 and April 2021. Logistic regression models were used to compare the groups with regard to frailty as assessed using multidimensional geriatric tools.

Results

We included 123 patients (68 HF + ATTRwt+ and 55 HF + ATTRwt

SUBMITTER: Broussier A 

PROVIDER: S-EPMC11769631 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature