Assessing the causal effect of inflammation-related genes on myocarditis: A Mendelian randomization study.

ABSTRACT:

Aims

Prior evidence has shown a significant link between inflammation and the development of myocarditis. This study aimed to investigate the causal relationship between inflammation-related genes (IRGs) and myocarditis.

Methods and results

In this study, the causal relationship between 167 IRGs and myocarditis were investigated using datasets from the Gene Set Enrichment Analysis and Integrative Epidemiology Unit open genome-wide association study (IEU OpenGWAS) databases. The GWAS data (finn-b-I9 MYOCARD) contained single nucleotide polymorphisms (SNPs) data from 117 755 myocarditis samples (16 379 455 SNPs, 829 cases vs. 116 926 controls). Five algorithms [MR-Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode regression] were employed

SUBMITTER: Xiao H 

PROVIDER: S-EPMC11769633 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature