Urine chloride trajectory and relationship with diuretic response in acute heart failure.

ABSTRACT:

Aims

Sodium excretion is a well-defined marker used to assess diuretic response in acute heart failure (AHF). Despite a strong pathophysiological background, the role of urine chloride excretion has not been described and established yet. We aimed to evaluate chloride trajectory during intensive diuretic treatment in AHF patients and examine its potential role in predicting poor diuretic response.

Methods

The study was conducted on 50 AHF patients. Participants were included within the first 36 h of hospitalization. They received furosemide dose adjusted for body weight (half in bolus, half in 2 h infusion). Post-diuretic hourly urine collection with biochemical analysis was performed.

Results

In general, the concentrations of urine chloride (uCl^-) and sodi

SUBMITTER: Guzik M 

PROVIDER: S-EPMC11769642 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature