Ketogenic diet treatment for super-refractory status epilepticus in the intensive care unit: feasibility, safety and effectiveness.

ABSTRACT:

Background and aims

To investigate the feasibility, safety and effectiveness of the ketogenic diet (KD) for super-refractory status epilepticus (SRSE) in the intensive care unit (ICU).

Methods

We conducted a prospective investigation on patients with SRSE treated with the KD. The primary outcome measures were ketosis development as a biomarker of feasibility and resolution of SRSE as effectiveness. KD-related side effects were also investigated.

Results

Twelve patients (9 females and 3 males) with SRSE, with a median age of 34 years [range 16-69, interquartile range (IQR) 18-52], were treated with a KD. The median duration of SRSE prior to KD treatment was 21 days (range 4-46). SRSE resolved in 75% (9/12) of patients at a median of 3 days (range 1-18) after KD initiat

SUBMITTER: Ren Y 

PROVIDER: S-EPMC11769800 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature